Cardiovascular disease is the most common cause of death world-wide. It is also the leading cause of hospital admissions and of physical disability and a major cost burden in health care. Cardiovascular disorders have multifactorial etiologies and affect almost all organ systems. Diagnosis, treatment and research endeavors focusing on these disorders therefore require close collaboration across medical specialties. The Cardiovascular Cluster is a multidisciplinary research structure which aims to facilitate synergies between basic and clinical investigators that span the spectrum of cardiovascular research.